El descubrimiento de nuevos inhibidores para proteínas específicas es crucial en la investigación farmacológica, especialmente en enfermedades autoinmunes, donde la desregulación de proteínas como la PAD4 (Peptidil Arginina ...

Ketamine hydrochloride serves multiple purposes, including its use as a general anesthetic, treatment for depression, and recreational drug. In studies involving rodents, ketamine is utilized as a model for schizophrenia ...

Introducción: Streptococcus mutans y Streptococcus sobrinus son las principales bacterias implicadas en la desmineralización del esmalte dental, responsable de las caries. Sin embargo, ciertos grupos de bacterias ...

Pseudomonas aeruginosa is an opportunistic pathogen in HAIs with two facets: the most studied is the high rate of antimicrobial resistance, and the less explored is the long list of virulence factors it possesses. /is ...

Atherosclerosis, a chronic inflammatory disease of the arteries, is primarily driven by the accumulation of low-density lipoproteins (LDL) and remnant lipoprotein particles, which initiate an inflammatory response in ...

The Peritumoral Brain Zone (PBZ) contributes to Glioblastoma (GBM) relapse months after the resection of the original tumor, which is influenced by a variety of pathological factors. Among those, microglia are recognized ...

Resumen Las enfermedades cardiovasculares (ECV), son un grupo de trastornos que afectan al corazón y a los vasos sanguíneos, representan la principal causa de mortalidad y morbilidad, tanto a nivel mundial como en ...

The essential yeast protein GPN-loop GTPase 1 (Npa3) plays a critical role in RNA polymerase II (RNAPII) assembly and subsequent nuclear import. We previously identified a synthetic lethal interaction between mutants ...

Motor deficits observed in Parkinson’s disease (PD) are caused by the loss of dopaminergic neurons and the subsequent dopamine depletion in different brain areas. The most common therapy to treat motor symptoms for ...

Objectives. Peripheral and follicular helper T lymphocytes (Tph and Tfh, respectively) have an important role in B cell immune responses and the pathogenesis of rheumatoid arthritis (RA) and systemic lupus erythematosus ...