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Quantitative analysis of circulating T peripheral and follicular helper lymphocytes in patients with rheumatoid arthritis and systemic lupus erythematosus

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dc.contributor Roberto Fidencio González Amaro;3769 es_MX
dc.contributor ESTHER LAYSECA ESPINOSA;31310 es_MX
dc.contributor DIANA PATRICIA PORTALES PEREZ;21049 es_MX
dc.contributor MARIANA HAYDEE GARCIA HERNANDEZ;160017 es_MX
dc.contributor.advisor González Amaro, Roberto es_MX
dc.contributor.advisor Layseca Espinosa, Esther es_MX
dc.contributor.advisor Portales Pérez, Diana Patricia es_MX
dc.contributor.advisor García Hernández, Mariana Haydee es_MX
dc.contributor.author Sánchez Gutiérrez, Raquel es_MX
dc.coverage.temporal México. San Luis Potosí. San Luis Potosí es_MX
dc.creator RAQUEL SANCHEZ GUTIERREZ;622242 es_MX
dc.date.accessioned 2023-11-16T18:11:43Z
dc.date.available 2028-11-30
dc.date.available 2023-11-16T18:11:43Z
dc.date.issued 2023-11
dc.identifier.uri https://repositorioinstitucional.uaslp.mx/xmlui/handle/i/8443
dc.description.abstract Objectives. Peripheral and follicular helper T lymphocytes (Tph and Tfh, respectively) have an important role in B cell immune responses and the pathogenesis of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Although several studies on the number of Tph and Tfh cells in these conditions have been published, different phenotypes have been employed for their analysis. In this study, we assessed the levels and function of Tph and Tfh cells in blood samples from patients with RA and SLE using an extended immunophenotype. Methods. In a cross-sectional pilot study, blood samples from twenty-seven patients with RA and fifteen with SLE, and twenty-six healthy controls were studied. The levels of Tph cells (CD4+ PD-1 +CXCR5-CD38+CD69 + ICOS+) and Tfh cells (CD4+ PD-1+CXCR5+CD38+CD69+ICOS+) were analyzed by flow cytometry. In addition, the synthesis of IL-21 by these lymphocytes and the number of circulating plasmablasts (CD19+CD27+CD20-CD38hi) were determined. Results. Increased percentages of Tph and Tfh lymphocytes were detected in patients with RA and SLE. Furthermore, the synthesis of IL-21 tended to be higher in both conditions, and higher levels of plasmablasts were detected in these patients, compared to controls. In patients with SLE, the number of Tph cells was associated with disease activity and circulating plasmablast levels, while in patients with RA a significant correlation between Tph cells and evolution time was observed. Conclusions. Our data on Tph and Tfh lymphocytes, based on the analysis of an extended phenotype of these cells, provides further evidence of their involvement in the pathogenesis of RA and SLE. es_MX
dc.description.statementofresponsibility Investigadores es_MX
dc.description.statementofresponsibility Estudiantes es_MX
dc.language Inglés es_MX
dc.publisher Facultad de Medicina es_MX
dc.rights Acceso Embargado es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0 es_MX
dc.subject T peripheral helper cells es_MX
dc.subject T follicular helper cells es_MX
dc.subject Interleukin-21 es_MX
dc.subject Plasmablasts es_MX
dc.subject Autoimmune Diseases es_MX
dc.subject Receptores de interleucina-21(bvs) es_MX
dc.subject Linfoma plasmablástico (bvs) es_MX
dc.subject Enfermedades autoinmunes (bvs) es_MX
dc.subject Tesis académica (bvs) es_MX
dc.subject.other MEDICINA Y CIENCIAS DE LA SALUD es_MX
dc.title Quantitative analysis of circulating T peripheral and follicular helper lymphocytes in patients with rheumatoid arthritis and systemic lupus erythematosus es_MX
dc.type Tesis de doctorado es_MX
dc.degree.name Doctorado en Ciencias Biomédicas Básicas es_MX
dc.degree.department Facultad de Medicina es_MX


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