Respuesta inmune producida por plaquetas durante la infección con Mycobacterium tuberculosis

Torres Juárez, Flor de María

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Doctorado en Ciencias Biomédicas Básicas
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dc.contributor	Bruno Rivas-Santiago;0000-0002-1521-1519	es_MX
dc.contributor	Esther Layseca-Espinosa;0000-0002-2824-5486	es_MX
dc.contributor.advisor	Rivas Santiago, Bruno
dc.contributor.advisor	Layseca Espinosa, Esther
dc.contributor.author	Torres Juárez, Flor de María
dc.coverage.spatial	Zacatecas. Zacatecas. México	es_MX
dc.creator	FLOR DE MARIA TORRES JUAREZ;614497	es_MX
dc.date.accessioned	2022-08-31T16:24:23Z
dc.date.available	2022-08-31T16:24:23Z
dc.date.issued	2020-10
dc.identifier.uri	https://repositorioinstitucional.uaslp.mx/xmlui/handle/i/7930
dc.identifier.uri	https://doi.org/10.1016/j.micpath.2021.104768	en
dc.description.abstract	Tuberculosis (TB) is the first cause of death by a single infectious agent. Previous reports have highlighted the presence of platelets within Tb granulomas, albeit the immune-associated platelet response to Mycobacterium tuberculosis (Mtb) has not be deeply studied. Our results showed that platelets are recruited into the granuloma in the late stages of tuberculosis. Furthermore, electron-microscopy studies showed that platelets can internalize Mtb and produce host defense peptides (HDPs), such as RNase 7, HBD2 and hPF-4 that bind to the internalized Mtb. Mtb-infected platelets exhibited higher transcription and secretion of IL-1ß and TNF-α, whereas IL-10 and IL-6 protein levels decreased. These results suggest that platelets participate in the immune response against Mtb through HDPs and cytokines production.	es_MX
dc.description.sponsorship	CONACYT, Beca 614497	es_MX
dc.description.sponsorship	Proyecto R-2015-785-075, Financiamiento FIS/IMSS/PROT/PRIO/16/051, IMSS	es_MX
dc.description.statementofresponsibility	Investigadores	es_MX
dc.description.statementofresponsibility	Estudiantes	es_MX
dc.language	Inglés	es_MX
dc.relation.ispartof	REPOSITORIO NACIONAL CONACYT	es_MX
dc.relation.requires	RNase 7 but not psoriasin nor sPLA2-IIA associates with Mycobacterium tuberculosis during airway epithelial cell infection, 2018, Research article	es_MX
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dc.relation.requires	Glucose levels affect LL-37 expression in monocyte-derived macrophages altering the Mycobacterium tuberculosis intracellular growth control, 2016, Research article	es_MX
dc.relation.uri	https://doi.org/10.1093/femspd/fty054	es_MX
dc.relation.uri	https://doi.org/10.1016/j.arcmed.2020.03.006	es_MX
dc.relation.uri	https://doi.org/10.1111/cei.13388	es_MX
dc.relation.uri	https://doi.org/10.2174/1381612825666190628152842	es_MX
dc.relation.uri	https://doi.org/10.2174/1381612824666180327162357	es_MX
dc.relation.uri	http://dx.doi.org/10.1016/j.tube.2017.07.005	es_MX
dc.relation.uri	http://dx.doi.org/10.1080/08820139.2016.1212873	es_MX
dc.relation.uri	http://dx.doi.org/10.1016/j.micpath.2016.06.002	es_MX
dc.rights	Acceso Abierto	es_MX
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0	es_MX
dc.subject	Tuberculosis	es_MX
dc.subject	platelets	es_MX
dc.subject	immune response	es_MX
dc.subject	host defense peptides	es_MX
dc.subject.other	BIOLOGÍA Y QUIMICA	es_MX
dc.subject.other	MEDICINA Y CIENCIAS DE LA SALUD	es_MX
dc.title	Respuesta inmune producida por plaquetas durante la infección con Mycobacterium tuberculosis	es_MX
dc.title.alternative	Platelets immune response against Mycobacterium tuberculosis infection	en
dc.type	Tesis de doctorado	es_MX
dc.degree.name	Doctorado en Ciencias Biomédicas Básicas	es_MX
dc.degree.department	Facultad de Medicina	es_MX